Which Pill is Best for Birth Control?
- Duly Care
- Apr 24
- 9 min read
Birth control pill, commonly known as "the pill", are an effective method of preventing pregnancy. Choosing the right birth control pill can feel overwhelming with so many options available. From combined oral contraceptive pills to progestin-only pills, different formulations cater to different needs.
Understanding the types of birth control pills, such as the 21-pill pack, 24-pill pack, combined oral contraceptive pill (COCP), and progestin-only pill (POP), can help you make an informed decision. This guide explains the different types of birth control pills, their benefits, and how to know the best pill.
Key Takeaways:
Types of Pills: The two main types of birth control pills are combined oral contraceptive pills (COCPs), which contain both estrogen and progestin, and progestin-only pills (POPs), which do not contain estrogen.
Dosage Options: Pills come in different pack sizes, such as 21-day packs, 24-day packs, and extended-cycle packs, affecting how and when you take them.
Benefits: Different pills offer additional advantages like lighter periods and reduced acne but may also come with side effects.
Choosing the Best Pill: Factors like menstrual regulation, hormonal sensitivity, medical history, and personal preference determine the best pill for you.
Combined Oral Contraceptive Pills (COCPs)

COCPs contain two hormones, estrogen and progestin, which work together to prevent pregnancy through three main mechanisms:
Preventing ovulation: Prevents the ovaries from releasing an egg.
Thickening cervical mucus: Creates a sticky barrier at the entrance of the uterus, making it harder for sperm to swim through and reach the egg.
Thinning the uterine lining: Makes the inside of the uterus less suitable for a fertilized egg to attach and grow, reducing the chances of pregnancy.
These pills come in different pack sizes and hormone regimens, allowing for flexibility and management of the menstrual cycle and its symptoms.
Finding the Best Formulation
Choosing the best birth control pill can be challenging, and one of the reasons for this is the complex formulation of the pill. The pill contains a mix of two main ingredients: estrogen and progestin. These two hormones come in different dosages and types, and each combination can affect your body in unique ways.
Every woman’s body responds differently to these hormones, finding the right formulation can be a process of trial and error. Let’s break it down a bit further so you understand why the right combination can be so tricky to find.
Estrogen Dosages
Estrogen is one of the key hormones in birth control pills, and its dosage can vary. Most pills contain 20-35 micrograms (mcg) of estrogen, but some formulations have lower doses (10 or 20 mcg) or higher doses (50 mcg). The dosage of estrogen affects how your body reacts to the pill, and finding the right dose is critical in minimizing unwanted side effects, like nausea, headaches, or bloating.
Low-dose estrogen (10-20 mcg): Pills with a lower dose of estrogen tend to have fewer estrogenic side effects, especially nausea and bloating. However, some women may find that these pills may cause spotting between periods.
Standard-dose estrogen (30-35 mcg): This is the most common estrogen dose in birth control pills and is usually effective at preventing pregnancy. However, it may cause side effects, like spotting, bloating or mood swings, in some women.
High-dose estrogen (50 mcg): High-dose pills are less commonly used today, but some women may need a higher dose if they have specific medical conditions (such as severe acne or irregular cycles). These pills may also be linked to a higher risk of side effects like nausea, headaches, or increased risk of blood clots, especially in smokers or women over 35.
Progestin Types

Progestin is a synthetic version of the hormone progesterone, and it is another essential part of birth control pills. Progestins used in birth control pills are classified by “generations,” based on when they were developed and how they interact with the body. Each generation can affect mood, skin, weight, and bleeding patterns differently. Understanding these categories can help in finding the right pill, especially for those sensitive to certain side effects.
First-Generation Progestins: These were the earliest types developed. They are effective in preventing pregnancy but may have stronger androgenic effects (testosterone-like effects such as acne or increased hair growth) in some users. Example: Norethindrone
Second-Generation Progestins: These progestins are more potent and longer-acting. They may also have androgenic effects, but often less than the first generation. Some users experience more stable bleeding patterns on these. Example: Levonorgestrel
Third-Generation Progestins: Designed to reduce androgenic effects, these progestins are often chosen by people who are prone to acne, oily skin, or mood changes. They are generally considered more skin-friendly .Examples: Desogestrel, Norgestimate
Fourth-Generation Progestins: These are the newest types and have anti-androgenic properties, meaning they may help with acne, bloating, and water retention. However, some studies suggest a slightly higher risk of blood clots with these, especially in individuals with other risk factors. Example: Drospirenone
Each generation has its benefits and trade-offs, and the best choice depends on individual health needs, lifestyle, and how the body reacts to different hormone levels. Consulting a doctor is key to choosing the most suitable option.
Why It’s Hard to Find the Right Pill for You
The difficulty in finding the right birth control pill formulation lies in the balance of these ingredients. Each woman’s body responds differently to the levels of estrogen and the type of progestin, and a pill that works well for one person may cause side effects or be ineffective for someone else.
Finding the best pill often involves working closely with a doctor to figure out which combination works best for you. It can take time and adjustments to find a pill that provides effective contraception while minimizing side effects. Many women may have to try different formulations before finding the one that suits them.
Dosing Regimens
a) 21-Day Pack
How it works: Take one active pill daily for 21 days, followed by a 7-day break during which no pills are taken (or inactive pills are used). During this break, a withdrawal bleed (period-like bleeding) occurs.
Who it is for: Ideal for those who prefer a regular, predictable cycle with a scheduled period. It follows a pattern similar to a natural menstrual cycle, making it a familiar option for many users.
Things to Consider: Strict adherence is essential to prevent unintended ovulation during the pill-free week.
b) 24-Day Pack
How it works: Take 24 active pills, followed by 4 inactive pills (or a hormone-free interval). This shortens the duration of hormone-free days, which may lead to fewer symptoms like headaches and mood swings during the pill break.
Who it is for: Suitable for individuals who experience hormone withdrawal symptoms in the typical 7-day break and want to minimize these symptoms.
Things to Consider: The shortened hormone-free phase can help reduce fluctuations in hormone levels, making it beneficial for people with hormone-sensitive conditions like migraines.
c) Extended-Cycle Pills (91-Day Pack)
How it works: Take 84 active pills continuously, followed by 7 inactive pills. This results in only four periods per year.
Who it is for: Those who prefer fewer periods or experience painful, heavy, or inconvenient menstruation.
Things to Consider: Some users may experience breakthrough spotting or irregular bleeding, especially in the first few months. However, this usually stabilizes over time.
Progestin-Only Pills (POP) – The Mini Pill

Unlike COCP pills, progestin-only pills contain no estrogen. They are often prescribed for individuals who cannot take estrogen due to medical conditions or specific life stages.
How it works:
Who it is for:
Women who are breastfeeding, as estrogen-containing pills can affect milk production.
Individuals at higher risk of cardiovascular issues (e.g., those with high blood pressure, smokers over 35, or those with a history of blood clots).
People who experience migraine with aura, as estrogen can trigger or worsen these headaches.
Things to Consider:
Unlike COCPs, POPs must be taken at the same time every day for maximum effectiveness. A delay of just a few hours can reduce their reliability.
POPs may cause more frequent spotting or irregular periods, though this often stabilizes with consistent use.
Which is the Best Birth Control Pill?

Choosing the right birth control pill depends on individual health needs, lifestyle preferences, and how the body responds to different hormone combinations. While all pills are 99% effective when taken correctly, selecting the most suitable one can improve overall comfort and adherence.
Based on Health Conditions
Certain health conditions influence which type of birth control pill is safest and most beneficial:
Heavy or Painful Periods: If you experience heavy menstrual bleeding or painful cramps, a combined oral contraceptive pill (COCP) with a 24-day pack can help regulate cycles and reduce menstrual discomfort by shortening the hormone-free interval. Some extended-cycle pills can even help reduce the number of periods per year.
History of Blood Clots or Cardiovascular Issues: If you have a history of blood clots, high blood pressure, or are at risk for heart disease, progestin-only pills (POPs) are a safer alternative since estrogen-containing pills can increase the risk of clot formation.
Acne and Hormonal Imbalances: Some COCPs contain anti-androgenic progestins (such as cyproterone acetate and drospirenone), which help reduce acne and control excessive oil production. These pills are often prescribed for those with hormonal acne or polycystic ovary syndrome (PCOS).
Migraines with Aura: Estrogen-containing pills can trigger migraines with aura, increasing the risk of stroke. In such cases, POPs or low-dose estrogen COCPs are safer alternatives.
Breastfeeding: Progestin-only pills are recommended for new mothers since estrogen can affect milk production.
Based on Lifestyle Preferences
Different pill regimens offer flexibility to match individual schedules and period preferences:
Regular Monthly Cycles: If you prefer a scheduled period every month, you can opt for a 21-day or 24-day COCP pack. These maintain a consistent cycle, mimicking a natural menstrual rhythm.
Fewer Periods: If you want to reduce the frequency of your periods, an extended-cycle pill (91-day pack) can help by limiting menstruation to four times a year.
Forgetfulness or Inconsistent Schedule: If you struggle to take pills at the same time daily, a COCP may be more forgiving than a POP, which requires strict timing. Some COCPs allow a 12-24 hour window, whereas POPs must be taken at the exact same time each day to maintain effectiveness.
Based on Side Effects
Side effects vary from person to person, and switching pill formulations can often help manage them:
Bloating and Nausea: Low-dose estrogen pills can help minimize bloating and nausea, especially in those sensitive to higher hormone levels.
Mood Swings: Some people experience mood fluctuations due to the type of progestin used in their pill. Switching to a different progestin formulation (e.g., one with anti-androgenic properties) may help stabilize mood.
Acne or Hair Fall: Androgenic progestins may contribute to increased acne or hair fall in some users. Switching to a pill with lower androgenic activity or anti-androgenic effects can sometimes reduce these symptoms.
It is not advisable to switch the pill yourself, always consult a doctor to make this change.
Conclusion
With multiple options available, understanding how different pills work and their effects can empower you to make an informed choice. Finding the right birth control pill is a deeply personal decision that goes beyond just preventing pregnancy - it is about choosing a method that supports your overall well-being, aligns with your lifestyle, and makes you feel comfortable in your body.
Whether you’re seeking better cycle control, relief from hormonal concerns, or a low-maintenance contraceptive, the best pill is the one that meets your unique needs. If you're unsure where to start, speaking to a doctor can help you navigate your options with confidence.
Frequently Asked Questions (FAQs)
How do I choose the best birth control pill?
Consider factors like health conditions, medical history, lifestyle and preferences. A doctor can help determine the most suitable option.
Are progestin-only pills as effective as combined oral contraceptive pills?
Yes, when taken correctly, POPs are over 99% effective, but they must be taken at the same time every day for the best results.
Can I switch from one pill to another?
Yes, but consult a doctor to ensure a smooth transition and avoid gaps in protection.
Important
This blog, including its text, images, and infographics, is for educational purposes only and not a substitute for professional medical advice. For personalized advice, always consult a doctor.
Further Reading
For more details on this or related topics, refer to the papers listed in references below, or check out the other blogs on our website dulycare.in.
References
UK National Health Service. Combined Contraceptive Pill. 2023. https://www.nhs.uk/conditions/contraception/combined-contraceptive-pill
The Faculty of Sexual and Reproductive Healthcare. Combined Hormonal Contraception. 2023. https://www.fsrh.org/standards-and-guidance/documents/combined-hormonal-contraception/
International Journal of Endocrinology & Metabolism. Non-Contraceptive Benefits of Oral Hormonal Contraceptives. 2013. https://ijem.sums.ac.ir/article_4158.html
American College of Obstetricians and Gynecologists (ACOG). Birth Control. Accessed on 7 February 2025. https://www.acog.org/womens-health/faqs/birth-control
Mayo Clinic. Choosing a Birth Control Pill. Accessed on 28 December, 2024. https://www.mayoclinic.org/healthy-lifestyle/birth-control/in-depth/best-birth-control-pill/art-20044807
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